Patient-centricity has become a cornerstone of clinical research, emphasising the importance of involving patients as active partners in study design and execution. This approach enhances recruitment, retention, and the overall success of clinical trials while aligning with the evolving regulatory landscape. Recent FDA guidance, along with our own National Statement on ethical conduct in clinical trials, underscores the necessity of integrating the patient voice in medical device and drug development, emphasising transparency, inclusivity, and relevance in trial design.    This presentation explores innovative strategies to amplify patient-centricity, focusing on harnessing social media to broaden reach and improve recruitment. Platforms such as Instagram and Facebook allow researchers to engage diverse populations, ensuring that underrepresented groups are included in trials. To overcome linguistic and cultural barriers, advanced language translation tools facilitate meaningful communication, ensuring accessibility and comprehension for all participants.    Incorporating patient-focused feedback into protocol development is pivotal. Patient advisory groups provide critical insights into study feasibility, burden, and acceptability, fostering designs that align with real-world patient needs. Additionally, the evolution of in-stay clinical trial units mirrors a hospitality approach, offering hotel-like accommodations with recreational areas and outdoor spaces. These environments enhance participant comfort, contributing to positive experiences and improved compliance.    This session also highlights the operationalisation of the patient engagement recommendations, showcasing practical methods to incorporate the patient’s voice into every phase of clinical trials. By prioritising patient well-being, comfort, and perspectives, we can enhance the reliability of study outcomes and the overall value of clinical research.    The integration of these strategies represents a paradigm shift in clinical research, setting a new standard for patient engagement. Attendees will leave equipped with actionable tools to design and conduct more inclusive and engaging clinical trials.